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James Dewey Watson (born April 6, 1928) is an American molecular biologist, geneticist, and zoologist. In 1953, he co-authored with Francis Crick the academic paper proposing the double helix structure of the DNA molecule. Watson, Crick and Maurice Wilkins were awarded the 1962 Nobel Prize in Physiology or Medicine “for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material”. In subsequent years, it has been recognized that Watson and his colleagues did not properly attribute colleague Rosalind Franklin for her contributions to the discovery of the double helix structure.
Francis Harry Compton Crick OM FRS (8 June 1916 – 28 July 2004) was an English molecular biologist, biophysicist, and neuroscientist. He, James Watson, Maurice Wilkins and Rosalind Franklin played crucial roles in deciphering the helical structure of the DNA molecule. Crick and Watson’s paper in Nature in 1953 laid the groundwork for understanding DNA structure and functions. Together with Maurice Wilkins, they were jointly awarded the 1962 Nobel Prize in Physiology or Medicine “for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material”.
Below is a recent realized price for a Molecular Structure Nucleic Acids Offprint 1953 item. We at Nate D. Sanders Auctions can obtain up to this amount or more for you:
Molecular Structure Nucleic Acids Offprint 1953. Sold for over $10,000.
Here are some recent items that our auction house, Nate D. Sanders (http://www.NateDSanders.com), has sold:
James Watson and Francis Crick Signed First Day Cover — With a Drawing by Watson of a DNA Double Helix — With PSA/DNA COA
Nobel Prize winning scientists, James Watson and Francis Crick signed FDC, with a drawing of their discovery — the infamous double helix strand of DNA. Signed “James D. Watson” and “Francis Crick”, Watson also draws the double helix, marking it as “DNA” and identifying it as either a “D-T” or “G-C” strand. Postmarked Washington DC, 21 September 1983, first day cover honors Edwin H. Armstrong who invented the FM radio. Measures 6.5″ x 3.5″. Near fine condition. With PSA/DNA COA. Sold for $3,884.
Fantastic Maurice Wilkins autograph manuscript signed, with highly detailed content regarding a March 1953 letter Wilkins had written to Francis Crick after seeing the Watson & Crick double-helix for the very first time, including numerous references to Rosalind Franklin, who many credit with first discovering the DNA helix. Dated 17 October 1999, three page document is signed ”MHF Wilkins” at the top right of each page, and is accompanied by a photocopy of the original 3 March 1953 letter to Crick on ”Kings College” letterhead.
The last section of the manuscript refers particularly to the famed April 1953 ”Nature” magazine debuting DNA as a double helix structure that made Wilkins, Watson & Crick famous: ”…Gale was the editor of Nature and since he knew both Bragg & Randall there was no difficulty, so far as I was aware, to arrange for the Cambridge letter to be held back a little so that the two letters from King’s could be published alongside the Cambridge letter. Francis was a bit anxious that Pauling might suddenly produce the solution and ‘beat them to the post’. But, as I felt it, he was quite reasonable and I did not feel much tension…” Last page also includes two hand-drawn illustrations of the double helix and its structure. Three page manuscript on three sheets measures 8.25” x 11.625”. Staple punctures at top left and very light wear. Near fine condition. Sold for $3,750.
Francis Crick and James Watson Signed Illustration of the DNA Double Helix — With PSA/DNA COA
Francis Crick and James Watson signed illustration of the DNA double helix. The Nobel Prize winning scientists sign in fine black felt-tip and black ballpoint respectively: ”Francis Crick / James D. Watson”, without inscription. Printed illustration shows how two strands of DNA on the left, resembling a ladder, ”are twisted around each other to make a double helix.” Measures 8.5” x 11”. Near fine. With PSA/DNA COA for both signatures. Sold for $2,500.
Maurice Wilkins Autograph Manuscript Signed re DNA
Superb Maurice Wilkins autograph manuscript signed, dated 22 October 1999. Comprehensive manuscript on one page discusses a November 1948-9 letter Wilkins had written to Francis Crick as their relationship was blossoming and their preliminary ideas of DNA’s true structure were still being explored. Photocopy of the original letter is included which also bears his signature, “MHF Wilkins” and additionally, a small annotation in his hand: “Set of letters to Crick (showing my notes in red)”. Manuscript is written in black ink with a bold “MHF Wilkins” signed at the upper right corner. Reads in full: “Set of My Comment on the Letters to Crick / 22 Oct. 99 / Extra letter, probably the first I wrote to Crick. 1948-9 / In 1948 I was busy with microspectroscopy of living cells studying the changes in DNA in chromosome in dividing tissue culture cells; but I was also moving towards the structure of DNA itself because we were very lucky in hearing about [Oswald] Avery’s [who discovered that DNA is the material of which genes and chromosomes are made] work from a biochemist who had worked near Avery in New York & gave good reasons to believe that Avery really had shown DNA (by itself) really was the gene material. Also Gerald Oster had been a very useful U.S. visitor who brought me up to date on Stanley’s (California) work on crystals of TMV virus. So I was edging away from DNA in cells towards molecular structure of DNA. Like most British scientists, Francis believed genes were protein. We were very lucky to get inside information about Avery! Later when Jim Watson came to Cambridge he told them (all working on protein crystals) a great deal more about DNA work by the U.S. Phage Group. Thus Francis joined up with Jim. (who had been switched on by seeing our crystalline DNA pattern at my Naples talk). At the time of this letter my scientific work did not overlap much with Francis’s work which had been forced on him by the MRC who employed him in the Strangeways lab at Cambridge. However, the spirit at dinner with Frances & Odile reminded me of my very lively times in Berkeley during the war.” Signed “MHF Wilkins” at upper right. Manuscript measures 8.25″ x 11.5″ with staple holes and the number “1” circled in pencil at top left. Near fine condition. Sold for $2,431.
James Watson Signed Drawing of the DNA Double Helix — Also Signed by Francis Crick
Francis Crick and James Watson signed sketch of a DNA double helix. The DNA strand is drawn by Watson who also writes, “A-T or G-C -> DNA”. Both men were awarded the Nobel Prize in 1962 for their discovery of DNA. Card measures 5.75″ x 4″. Near fine. Sold for $2,200.
DNA Scientists Francis Crick and James Watson Signed First Day Cover Honoring Health Research
Nobel Prize winning scientists, James Watson and Francis Crick signed first day cover honoring ”Health Research”, rare as signed by both DNA discoverers: ”James D. Watson” and ”Francis Crick”. Cover promoting Health Research has the Colorano Silk Cachet, postmarked New York, 17 May 1984. Measures 6.5” x 3.5”. Near fine condition. Sold for $1,500.
Maurice Wilkins Autograph Manuscript Signed re DNA
Fantastic Maurice Wilkins autograph manuscript signed, discussing a 21 August 1952 postcard Wilkins had written to Francis Crick from Rio de Janeiro while attending an important scientific meeting. Included is a photocopy of that original postcard addressed to Crick at his lab in Cambridge. Manuscript, written in black ink, is on one page with a bold “MHF Wilkins” signed at the upper right corner. Wilkins describes the early working relationship between him and Rosalind Franklin, particularly with regards to x-ray diffraction, which they both were working on and which helped lead up to the discovery of DNA — a discovery many claim Rosalind Franklin should have earned credit. Reads in full: “Postcard 21 Aug 1952 was from Rio de Janeiro where I was invited to help stimulate biophysical research in Brazil. The postcard showed the enormous statue of Christ on a mountain top overlooking the city. I had invented a solid quartz microscope reflecting objective to study DNA in cells; but I had decided such research was of much less importance than DNA molecular structure studies with x-ray diffraction. The study of haemoglobin [sic] in human blood cells took little time and was the last research of that kind which I did. DNA structure & function was the big important problem. ‘The phage meeting was fascinating’ [citing his letter] refers to a very important international meeting in Paris on the way to Brazil. Jim Watson invited me to attend. The role of DNA in carrying genetic messages into phage and other viruses was becoming clear. At the phage meeting Jim Watson took me to his mentor Delbruck (the leader of the U.S. Phage Group who had been led by Niels Bohr before the war to take up biophysics). Just before I had left London for Rio Rosalind had called a meeting with Stokes and me (who were encouraged by x-ray evidence which pointed to DNA being helical). Rosalind showed us her latest data which appeared to show the helical idea was wrong. Having much respect for Rosalind as a reliable scientist, Stokes and I were persuaded that the very attractive helical ideas were not correct. I reported this to Delbruck who, as a result, was disillusioned with x-ray studies on DNA. Jim Watson, not having heard the details of Rosalind’s report, was not prepared to give up the helical idea, if there had not been a great rush to pack up my microscope & leave for Paris & Brazil maybe I could have examined Rosalind’s data more carefully; but everything appeared to be in good order. It was, however, only a few years ago that Gosling (who was a friendly joker) told me that it was not he who had written The Death of a Helix joke invitation sent to Stokes but that Rosalind had done it! Rosalind’s mother wrote that Rosalind was a great tease!” In the margin Wilkins writes: “I felt rather flattered that I had been chosen to be one of a small number of British scientists representing British biology at the Rio international meeting. / I find it disturbing that Rosalind indulged in a joke at a rare & critically important meeting”. Manuscript measures 8.25″ x 11.5″ with staple holes at top left and the number “4” circled in pencil, else fine condition. Sold for $1,469.
Signed Dr. Francis Crick Sketch
Francis Crick Autograph & DNA Sketch — 5″ x 7″ — Dr. Crick Awarded the 1962 Nobel Prize For His Work on DNA With James Watson — Excellent. Sold for $735.
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Molecular Structure Nucleic Acids Offprint 1953